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Image Search Results
Journal: The Journal of Biological Chemistry
Article Title: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells
doi: 10.1074/jbc.M117.790568
Figure Lengend Snippet: No influence of phototoxicity on retinal disruption in the LPAAT3-KO mice. Mice at 1–3 weeks old were maintained under dark conditions for 2 weeks, and their retinal layers were analyzed. OS/IS and ONL from LPAAT3-KO retinas were lower than those of WT retinas, with similar results to those under normal light/dark cycle conditions. LPAAT3-KO mice were not influenced by phototoxicity under the conditions. Four independent experiments were performed with similar results (hematoxylin and eosin staining). Results are expressed as the mean ± S.E. p value, Mann-Whitney U test. Experimental numbers of OS/IS were n = 5 in WT and n = 8 in LPAAT3-KO retinas from each four mice. ONL and INL were n = 8 from four retinas from each mouse.
Article Snippet: The abbreviations used are: DHA docosahexaenoic acid ERG electroretinogram PE phosphatidylethanolamine RPE retinal pigment epithelial LPC lysophosphatidylcholine PA phosphatidic acid PC phosphatidylcholine PL-DHA DHA-containing phospholipid OS outer segment PL phospholipid DLS dynamic light scattering MD
Techniques: Disruption, Staining, MANN-WHITNEY